Metabolic Changes Accompanying Spermatogonial Stem Cell Differentiation

Title: Metabolic Changes Accompanying Spermatogonial Stem Cell Differentiation
Creator: Lord, Tessa; Nixon, Brett
Relation: Developmental Cell Vol. 52, Issue 4, p. 399-411
Publisher Link: http://dx.doi.org/10.1016/j.devcel.2020.01.014
Publisher: Cell Press
Resource Type: journal article
Date: 2020
Description: Male fertility is driven by spermatogonial stem cells (SSCs) that self-renew while also giving rise to differentiating spermatogonia. Spermatogonial transitions are accompanied by a shift in gene expression, however, whether equivalent changes in metabolism occur remains unexplored. In this review, we mined recently published scRNA-seq databases from mouse and human testes to compare expression profiles of spermatogonial subsets, focusing on metabolism. Comparisons revealed a conserved upregulation of genes involved in mitochondrial function, biogenesis, and oxidative phosphorylation in differentiating spermatogonia, while gene expression in SSCs reflected a glycolytic cell. Here, we also discuss the relationship between metabolism and the external microenvironment within which spermatogonia reside.
Subject: spermatogonial stem cells; metabolism; mitochondria; spermatogenesis
Identifier: http://hdl.handle.net/1959.13/1438897
Identifier: uon:40758
Identifier: ISSN:1534-5807
Language: eng
Reviewed